ANTI-MONOMETHYL-HISTONE H3 (LYS18) ANTIB

Biochem/physiol Actions

Histones acts as structural scaffolds for DNA packaging. Histone H3 plays an important role in replication and DNA repair. Histone H3 is heavily post-translationally modified than the other members of histone family. Mutations in the gene leads to cerebellar high-grade gliomas. Phosphorylated histone H3 is implicated in the modulation of gene expression and in chromosome condensation/segregation. Monomethyl-histone H3 acts as a potent epigenetic mark for repressed euchromatin in Chlamydomonas.

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General description

Histone H3/ histone cluster 1 H3 family member a (HIST1H3A) is a core member of the histone family. HIST1H3A is encoded by the gene mapped to human chromosome 6p22.2. The encoded protein is composed of ~136 amino acids.

Immunogen

Synthetic peptide corresponding to Monomethyl-Histone H3 (Lys18)

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Specificity

This antibody reacts to Histone H3 monomethylated at Lysine 18 (K18me1). No cross reactivity with dimethylated Lysine 18 (K18me2) or trimethylated Lysine 18(K18me3), or other methylations in histone H3.